Bioorganic and Medicinal Chemistry Letters p. 1751 - 1756 (1999)
Update date:2022-07-30
Topics:
Zhang, Lijun
Williams, Matthew A.
Mendel, Dirk B.
Escarpe, Paul A.
Chen, Xiaowu
Wang, Ke-Yu
Graves, Bradford J.
Lawton, Geoff
Kim, Choung U.
1,4,5,6-Tetrahydropyridazine derivative 15 and its C-5 epimer 19, which possessed side chains similar to GS4071, were synthesized via a hetero Diels- Alder reaction, and evaluated as influenza neuraminidase inhibitors. Compounds 15 and 19 exhibited a μM range of influenza neuraminidase inhibitory activity.
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