Tetrahedron Letters p. 4711 - 4714 (1999)
Update date:2022-07-29
Topics:
Hidai, Yuko
Kan, Toshiyuki
Fukuyama, Tohru
The total synthesis of HO-416b (1) was accomplished using the 2- nitrobenzenesulfonamide (Ns) group as both a protecting and activating group. Starting with monosulfonylated diamines 2 and 3, three C-N bonds were constructed via alkylation of sulfonamides with alkyl halides. Removal of the Ns groups while the substrate was attached to a novel solid support enabled the efficient isolation of pure 1.
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Doi:10.1021/ja01308a035
(1935)Doi:10.1016/S0040-4020(99)00442-1
(1999)Doi:10.1039/b414747m
(2005)Doi:10.1021/op0341869
(2004)Doi:10.1002/(SICI)1099-0690(199908)1999:8<1831::AID-EJOC1831>3.0.CO;2-R
(1999)Doi:10.1002/(SICI)1521-3765(19990802)5:8<2270::AID-CHEM2270>3.0.CO;2-L
(1999)
