Il Farmaco p. 416 - 422 (1999)
Update date:2022-08-04
Topics:
Menozzi, Giulia
Mosti, Luisa
Bruno, Olga
Lo Presti, Eleonora
Musiu, Chiara
Longu, Silvia
La Colla, Paolo
Filippelli, Walter
Falcone, Giuseppe
Piucci, Brunella
A series of pyrazole analogues of bifonazole, an antifungal drug used in clinical practice, 2a-h and 4a-h were synthesized and tested in vitro against Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus, with no significant results. Imidazoles 2a-h were also tested in vivo for antiarrhythmic and antihypertensive activities; two of these compounds showed moderate activity against ventricular fibrillation caused by aconitine in rats. The above compounds were prepared by reaction of phenyl-[5 substituted 1-phenyl (or 1-methyl)-1H-pyrazol-4-yl]methanols with N,N'-carbonyldiimidazole (2a-h) or of the respective chloro derivatives with 1H-1,2,4-triazole (4a-h).
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Doi:10.1007/PL00010290
(1999)Doi:10.1021/jm990015b
(1999)Doi:10.1016/S0040-4039(98)00551-6
(1998)Doi:10.1021/np990132+
(1999)Doi:10.1016/S0040-4039(00)61166-8
(1992)Doi:10.1016/j.tet.2017.01.027
(2017)