Synthesis and triplex forming properties of pyrimidine derivative containing extended functionality

Article abstract of DOI:10.1080/07328319908044841

Two pyrimidine nucleosides have been synthesized containing extended hydrogen bonding functionality. In one case the side chain is based upon semicarbazide and in the second monoacetylated carbohydrazide was employed. DNA sequences could be prepared using both analogue nucleosides in a reverse coupling protocol, and provided that the normals capping step was eliminated and that the iodine-based oxidizing solution was replaced with one based upon 10-camphorsulfonyl oxaziridine. Both derivatives exhibited moderate effects in targeting selectively C-G base pairs embedded within a polypurine target sequences.

Full text of DOI:10.1080/07328319908044841

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Nucleosides and Nucleotides
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Synthesis and Triplex Forming Properties
of Pyrimidine Derivative Containing
Extended Functionality
Diego A. Gianolio a & Larry W. McLaughlin a
a Department of Chemistry , Merkert Chemistry Center , 2609
Beacon St., Chestnut Hill, MA, 02167
Published online: 04 Oct 2006.
To cite this article: Diego A. Gianolio & Larry W. McLaughlin (1999) Synthesis and Triplex Forming
Properties of Pyrimidine Derivative Containing Extended Functionality, Nucleosides and Nucleotides,
18:8, 1751-1769
To link to this article: http://dx.doi.org/10.1080/07328319908044841
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