Synthesis and structure-activity relationships of novel selective factor Xa inhibitors with a tetrahydroisoquinoline ring

DOI: 10.1021/jm058160e

Source and publish data:

Journal of Medicinal Chemistry p. 3586 - 3604 (2005)

Update date:2022-08-04

Topics:

Authors:

Ueno, Hiroshi

Yokota, Katsuyuki

Hoshi, Jun-Ichi

Yasue, Katsutaka

Hayashi, Mikio

Hase, Yasunori

Uchida, Itsuo

Aisaka, Kazuo

Katoh, Susumu

Cho, Hidetsura

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Article abstract of DOI:10.1021/jm058160e

A series of novel 2,7-disubstituted tetrahydroisoquinoline derivatives were designed and synthesized. Among these derivatives, compounds 1 and 2 exhibited potent inhibitory activity against factor Xa (FXa) and good selectivity with respect to other serine

Full text of DOI:10.1021/jm058160e

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Product name:2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-7-hydroxy-, phenylmethyl ester

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