Asymmetric synthesis of 1,2- and 1,4-dihydroquinolines

Article abstract of DOI:10.1016/S0040-4039(99)01172-7

Asymmetric synthesis of dihydroquinolines by addition of organometallic reagents on a chiral 3-quinolinyl aminal was studied. 1,2-Adducts were obtained with good regio- and diastereoselectivity. The absolute configuration for 1,2-adducts was determined by X-ray analysis and for 1,4- adducts by chemical correlation.