6-endo,6-endo,6-exo cascade cyclization starting from vinyl radical; construction of a dodecahydrophenanthrene system

DOI: 10.1016/S0040-4039(99)01234-4

Source and publish data:

Tetrahedron Letters p. 6277 - 6280 (1999)

Update date:2022-08-03

Topics:

Authors:

Takasu, Kiyosei

Kuroyanagi, Jun-ichi

Katsumata, Akira

Ihara, Masataka

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Article abstract of DOI:10.1016/S0040-4039(99)01234-4

Treatment of 1-iodo-1,5-diene 3 with Bu₃SnH at 80°C afforded the 6- endo cyclized product 6. The reaction was extended further to achieve the transformation of 1-iodo-1,5,9,14-tetraene 10 into dodecahydrophenanthrene 11 under one electron reductive conditions via 6-endo,6-endo,6-exo cascade cyclization.

Full text of DOI:10.1016/S0040-4039(99)01234-4

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