Synthesis and biological activity of a novel C4-C6 bridged paclitaxel analog

DOI: 10.1016/S0040-4020(99)00552-9

Source and publish data:

Tetrahedron p. 9707 - 9716 (1999)

Update date:2022-08-02

Topics:

Authors:

Yuan, Haiqing

Kingston, David G. I.

Sackett, Dan L.

Hamel, Ernest

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Article abstract of DOI:10.1016/S0040-4020(99)00552-9

The novel paclitaxel analog 15 with a bridge between the C-4 and C-6 positions was synthesized and was found to be less active than paclitaxel in in vitro tubulin assembly and cytotoxicity assays.

Full text of DOI:10.1016/S0040-4020(99)00552-9

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Product name:2'-O-(tert-butyldimethylsilyl)-2-debenzoyl-4-deacetyl-1,2-carbonato-6,7-dehydropaclitaxel

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