Parallel solid-phase synthesis of a model library of 7α-alkylamide estradiol derivatives as potential estrogen receptor antagonists

DOI: 10.1016/S0960-894X(99)00487-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2827 - 2832 (1999)

Update date:2022-08-03

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Authors:

Tremblay, Martin R.

Simard, Jacques

Poirier, Donald

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Article abstract of DOI:10.1016/S0960-894X(99)00487-4

The C17-THP derivative of 7α-(11-azidoundecanyl)-estradiol (4) was synthesized and coupled to an aminomethyl resin via a photolabile o-nitrobenzyl linker. Reduction of the azide by the Staudinger reaction to its corresponding amine followed by acylation u

Full text of DOI:10.1016/S0960-894X(99)00487-4

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