Synthetic approaches to biologically active bisphosphonates and phosphonocarboxylates

Article abstract of DOI:10.1080/10426509908546244

Some current and potential therapeutic uses of bisphosphonates and phosphonocarboxylates are summarized. The feasibility of synthesizing α-hydroxy α-alkyl/aryl methyl-enebisphosphonates via Grignard addition to tetraalkyl carbonylbisphosphonates 6 is demonstrated, and a new synthesis of 6 under very mild conditions is described.

Full text of DOI:10.1080/10426509908546244

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Phosphorus, Sulfur, and
Silicon and the Related
Elements
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Synthetic Approaches
to Biologically Active
Bisphosphonates and
Phosphonocarboxylates
Charles E. Mckenna, Boris A. Kashemirov
& Zeng-Min Li
a Department of Chemistry, University
of Southern California, Los Angeles, CA
90089–0744, USA
b Department of Chemistry, University
of Southern California, Los Angeles, CA
90089–0744, USA
c Department of Chemistry, University
of Southern California, Los Angeles, CA
90089–0744, USA
Version of record first published: 17 Mar
2008.
To cite this article: Charles E. Mckenna, Boris A. Kashemirov & Zeng-Min
Li (1999): Synthetic Approaches to Biologically Active Bisphosphonates and
Phosphonocarboxylates, Phosphorus, Sulfur, and Silicon and the Related
Elements, 144:1, 313-316

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