The design and synthesis of sulfur containing bisphosphonic acids for the treatment of arthritis

Article abstract of DOI:10.1080/10426509908546247

The sulfur containing bisphosphonic acids have been examined as a chondroprotective therapy for the treatment of arthritis. Several compounds have demonstrated both in vitro and in vivo activity. The newly synthesized compounds all contain a latent or a free thiol group which may bind to the zinc atom in the active site of the matrix metalloproteases. The in vivo activity of some of these bisphosphonic acids in the rat adjuvant model of arthritis is also discussed.

Full text of DOI:10.1080/10426509908546247

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Phosphorus, Sulfur, and
Silicon and the Related
Elements
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The Design and
Synthesis of
Sulfur Containing
Bisphosphonic Acids
for the Treatment of
Arthritis
Neil G. Almstead , Susan M. Dansereau ,
Marion D. Francis , Catherine M. Snider &
Frank H. Ebetino
a Procter and Gamble Pharmaceuticals,
Health Care Research Center, 8700
Mason-Montgomery Road, Mason, OH
45040, U.S.A.
b Procter and Gamble Pharmaceuticals,
Health Care Research Center, 8700
Mason-Montgomery Road, Mason, OH
45040, U.S.A.
c Procter and Gamble Pharmaceuticals,
Health Care Research Center, 8700
Mason-Montgomery Road, Mason, OH
45040, U.S.A.
d Procter and Gamble Pharmaceuticals,
Health Care Research Center, 8700

Mason-Montgomery Road, Mason, OH
45040, U.S.A.
e Procter and Gamble Pharmaceuticals,
Health Care Research Center, 8700
Mason-Montgomery Road, Mason, OH
45040, U.S.A.
Published online: 17 Mar 2008.
To cite this article: Neil G. Almstead , Susan M. Dansereau , Marion D.
Francis , Catherine M. Snider & Frank H. Ebetino (1999) The Design and
Synthesis of Sulfur Containing Bisphosphonic Acids for the Treatment of
Arthritis, Phosphorus, Sulfur, and Silicon and the Related Elements, 144:1,
325-328, DOI: 10.1080/10426509908546247
To link to this article: http://dx.doi.org/10.1080/10426509908546247
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