A general method for the synthesis of the N2- and N6- carcinogenic amine adducts of 2'-deoxyguanosine and 2'-deoxyadenosine

Article abstract of DOI:10.1021/ja991328z

A number of simple arylamino compounds (Figure 1) are well-established as pro-carcinogenic agents. Metabolic activation leads to a series of unstable N-hydroxy derivatives that on solvolysis, give nitrenium ions. The latter, which are regarded as the prim