A new efficient synthesis of efaroxan

DOI: 10.1016/S0960-894X(99)00531-4

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3021 - 3022 (1999)

Update date:2022-08-05

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Authors:

Mayer Mayer

Brunel Brunel

Imbert Imbert

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Article abstract of DOI:10.1016/S0960-894X(99)00531-4

The key step of the synthesis of efaroxan was the dihydrobenzofuran ring formation involving an intramolecular cyclization of the tertiary alcohol intermediate with the fluoroaromatic moiety in basic medium. This carbinol was prepared according to two rou

Full text of DOI:10.1016/S0960-894X(99)00531-4

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Product name:2-ethyl-3-(2-fluoro-phenyl)-oxirane-2-carboxylic acid ethyl ester

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