The synthesis and biological activity of a highly selective adenosine A(2a) receptor agonist

Article abstract of DOI:10.1080/07328319908044874

Three novel nucleosides 1, 2, and 3 were prepared that contained side chains at the 2-position of adenosine. Compound 1 was shown to be the most selective A(2a) receptor agonist reported to date having an A₁/A₂ ratio of 2400. In addition, compound 1 was shown to reduce blood pressure in rats and dogs with only minimal effects on heart rate.

Full text of DOI:10.1080/07328319908044874

Nucleosides and Nucleotides
ISSN: 0732-8311 (Print) (Online) Journal homepage: http://www.tandfonline.com/loi/lncn19
The Synthesis and Biological activity of a Highly
Selective Adenosine A2a. Receptor Agonist
David R. Borcherding , Nelsen L. Lentz , Philip M. Weintraub , Mark W.
Dudley , Roberta Secrest , Philip R. Kastner , Norton P. Peet & Hoechst
Marion Roussel
To cite this article: David R. Borcherding , Nelsen L. Lentz , Philip M. Weintraub , Mark W.
Dudley , Roberta Secrest , Philip R. Kastner , Norton P. Peet & Hoechst Marion Roussel (1999)
The Synthesis and Biological activity of a Highly Selective Adenosine A2a. Receptor Agonist,
Nucleosides and Nucleotides, 18:10, 2175-2191, DOI: 10.1080/07328319908044874
To link to this article: http://dx.doi.org/10.1080/07328319908044874
Published online: 04 Oct 2006.
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Date: 05 June 2016, At: 13:47