Efficient radical cyclisation of secondary amides: An enantioselective synthesis of phenyl allokainoid

DOI: 10.1016/S0040-4039(99)00431-1

Source and publish data:

Tetrahedron Letters p. 3487 - 3490 (1999)

Update date:2022-07-30

Topics: Enantioselective synthesis Secondary amides

Authors:

Bryans, Justin S.

Large, Jonathan M.

Parsons, Andrew F.

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Article abstract of DOI:10.1016/S0040-4039(99)00431-1

Cyclisation of various unsaturated haloamides with tributyltin hydride/AIBN has been explored. Substituted pyrrolidinones were isolated in good to excellent yield and the cyclisation of a serine-derived amide was utilised as the key step in an enantiosele

Full text of DOI:10.1016/S0040-4039(99)00431-1

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