Organic Process Research and Development p. 33 - 44 (2004)
Update date:2022-08-03
Topics:
Bowden, Sharon A.
Nigel Burke
Gray, Fiona
McKown, Steven
Moseley, Jonathan D.
Moss, William O.
Murray, Paul M.
Welham, Matthew J.
Young, Maureen J.
The manufacture of ZD2249 methoxy sulfoxide (1) using a new project approach is described. Research department processes were scaled up to 100 L if process safety and robustness were not compromised; other factors were treated according to the new approach. Using this strategy, we were able to manufacture a key intermediate on sufficient scale to support delivery of 1 kg quantities of bulk drug within 6 months of the start of lab work.
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Taizhou YOJOY Chemical Co., Ltd.
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Suzhou Chiral Pharmaceuticals Co., Ltd.
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Haitong Chemical Industrial Co.,Ltd.
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