The synthesis of bicyclic lactam based His-Pro building blocks: The effect of substituent polarity on an intramolecular bond migration

DOI: 10.1016/S0040-4039(99)01652-4

Source and publish data:

Tetrahedron Letters p. 7939 - 7943 (1999)

Update date:2022-08-03

Topics:

Authors:

Chu, Wenhua

Moeller, Kevin D.

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Article abstract of DOI:10.1016/S0040-4039(99)01652-4

A strategy for constructing bicyclic lactam amino acid building blocks with imidazole sidechains is reported. The synthetic route described utilizes an electrochemical amide oxidation to functionalize a proline derivative, and then a sequential cyclizatio

Full text of DOI:10.1016/S0040-4039(99)01652-4

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