3-Amidinophenylalanine-based inhibitors of urokinase

DOI: 10.1016/S0960-894X(99)00541-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3147 - 3152 (1999)

Update date:2022-08-03

Topics:

Authors:

Stuerzebecher, Joerg

Vieweg, Helmut

Steinmetzer, Torsten

Schweinitz, Andrea

Stubbs, Milton T.

Renatus, Martin

Wikstroem, Peter

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(99)00541-7

Synthesis and anti-uPA activity of a series of Nα-triisopropyl-phenylsulfonyl-protected 3-amidino-phenylalanine amides are described. We have explored SAR around the C-terminal amide part for inhibition of uPA, plasmin and trypsin. Modification of the ami

Full text of DOI:10.1016/S0960-894X(99)00541-7

Products guided by the article

Product name:1-[3-(3-cyano-phenyl)-2-(2,4,6-triisopropyl-benzenesulfonylamino)-propionyl]-piperidine-3-carboxylic acid

Cas No:255374-86-8

R&D Labs maybe for 255374-86-8

Sigma-Aldrich Chemie GmbH

website:http://www.sigmaaldrich.com

Contact:800 558-9160

Address:Industriestrasse 25CH-9471 Buchs SGSwitzerland
Yuan Shi(SuQian)Biotechnology Co.,Ltd

website:http://www.yuanshibio.com

Contact:+86-527-84226672

Address:jiangsu suqian
HANGZHOU FOREWIN PHARMA CO., LTD

Contact:+86-571-89053961

Address:hangzhou
Jingzhou TianHe Sci&Tech Chemical Co., Ltd.

Contact:86-716-8331612

Address:Jiangjin Road, #18, High-grade technology industries development district, Jingzhou city, Hubei province
Jiangxi Huashi Pharmaceutical Co., Ltd

Contact:+86-795-4509628

Address:No.199, Ningbo Avenue, Fengxin industrial park, Fengxin county, Yichun city, Jiangxi

Relevant to this article

Photolytic release of carboxylic acids using linked donor-acceptor molecules: Direct versus mediated photoinduced electron transfer to N-alkyl-4-picolinium esters

Doi:10.1021/ol050744n
(2005)
Palladium/P(t-Bu)₃-catalyzed synthesis of aryl t-butyl ethers and application to the first synthesis of 4-chlorobenzofuran

Doi:10.1016/S0040-4039(99)01855-9
(1999)
The synthesis of novel polyamine-nitroimidazole conjugates designed to probe the structural specificities of the polyamine uptake system in A549 lung carcinoma cells

Doi:10.1039/a903293b
(1999)
Design, synthesis and biological evaluation of 7-(aryl)-2,3-dihydro-[1,4]dioxino[2,3-g]quinoline derivatives as potential Hsp90 inhibitors and anticancer agents

Doi:10.1016/j.bmc.2016.12.050
(2017)
Application of the β-azidonation reaction to the enantioselective synthesis of the lycorane amaryllidaceae alkaloids

Doi:10.1016/S0040-4020(99)00850-9
(1999)
Highly Flexible Synthetic Routes to Functionalized Phospholanes from Carbohydrates

Doi:10.1021/jo991762j
(2000)

Article Doi