3-Amidinophenylalanine-based inhibitors of urokinase

DOI: 10.1016/S0960-894X(99)00541-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3147 - 3152 (1999)

Update date:2022-08-03

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Authors:

Stuerzebecher, Joerg

Vieweg, Helmut

Steinmetzer, Torsten

Schweinitz, Andrea

Stubbs, Milton T.

Renatus, Martin

Wikstroem, Peter

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Article abstract of DOI:10.1016/S0960-894X(99)00541-7

Synthesis and anti-uPA activity of a series of Nα-triisopropyl-phenylsulfonyl-protected 3-amidino-phenylalanine amides are described. We have explored SAR around the C-terminal amide part for inhibition of uPA, plasmin and trypsin. Modification of the ami

Full text of DOI:10.1016/S0960-894X(99)00541-7

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