The synthesis of 5-iodocytidine phosphoramidite for heavy atom derivatization of RNA

Article abstract of DOI:10.1016/S0040-4039(99)01650-0

The synthesis of an RNA phosphoramidite of 5-iodocytidine is reported. This heavy atom cytidine derivative was incorporated into four RNAs. Oligoribonucleotides with 5-iodocytidine will be useful for solving the X-ray crystallographic phase problem and for photochemical cross-linking studies.