The synthesis of 5-iodocytidine phosphoramidite for heavy atom derivatization of RNA

DOI: 10.1016/S0040-4039(99)01650-0

Source and publish data:

Tetrahedron Letters p. 8961 - 8964 (1999)

Update date:2022-07-31

Topics:

Authors:

Irani, Rostem J.

SantaLucia Jr., John

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Article abstract of DOI:10.1016/S0040-4039(99)01650-0

The synthesis of an RNA phosphoramidite of 5-iodocytidine is reported. This heavy atom cytidine derivative was incorporated into four RNAs. Oligoribonucleotides with 5-iodocytidine will be useful for solving the X-ray crystallographic phase problem and for photochemical cross-linking studies.

Full text of DOI:10.1016/S0040-4039(99)01650-0

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