An efficient one-pot route to symmetrically and unsymmetrically substituted 1,4,7-triazacyclononanes also results in the isolation of a stable macrocyclic aminal

Article abstract of DOI:10.1016/S0040-4039(99)01984-X

A one-pot methodology has been developed for the direct synthesis of symmetrically and unsymmetrically N-substituted derivatives of 1,4,7-triazacyclononane. In the course of these studies the unexpected eight-membered cyclic aminal 7 has been isolated via an acid-catalysed rearrangement of enamine 5.