Preparation of 14C-labelled 1,4-dideoxy-1,4-imino-D-arabinitol: Cyanosilylation of cyclic imines using KCN in a one-pot synthesis

DOI: 10.1002/(SICI)1099-1344(199912)42:12<1145::AID-JLCR268>3.0.CO;2-Y

Source and publish data:

Journal of labelled compounds and radiopharmaceuticals p. 1145 - 1159 (1999)

Update date:2022-08-05

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Authors:

Folkersen, Birgitte M.

Lundt, Inge

Foged, Christian

Valsborg, Jacob S.

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Article abstract of DOI:10.1002/(SICI)1099-1344(199912)42:12<1145::AID-JLCR268>3.0.CO;2-Y

A new method for C-C bond formation was developed based on in situ cyanosilylation of cyclic Schiff bases using KCN, TMSCl, KI and ZnI₂. This method was used to prepare the potent α-glucosidase inhibitor 1,4-dideoxy-1,4-imino-D-arabinitol

Full text of DOI:10.1002/(SICI)1099-1344(199912)42:12<1145::AID-JLCR268>3.0.CO;2-Y

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