Facile synthesis of optically active γ-lactones via lipase-catalyzed reaction of 4-substituted 4-hydroxybutyramides

DOI: 10.1248/cpb.48.304

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 304 - 305 (2000)

Update date:2022-08-05

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Authors:

Matsumura, Yasufumi

Endo, Teruko

Chiba, Mitsuo

Fukawa, Hidemichi

Terao, Yoshiyasu

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Article abstract of DOI:10.1248/cpb.48.304

Lipase-catalyzed transesterification of racemic 4-substituted 4- hydroxybutyramides with succinic anhydride proceeded enantioselectively to afford (S)-succinic acid monoester and unreacted (R)-4-hydroxybutyramide derivative, which were separated easily by

Full text of DOI:10.1248/cpb.48.304

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