Stereoselective synthesis and receptor binding of conformationally restricted and flexible 2,4-disubstituted 1,3-dioxanes derived from benzomorphans

DOI: 10.1002/(SICI)1521-4184(199912)332:12<413::AID-ARDP413>3.0.CO;2-0

Source and publish data:

Archiv der Pharmazie p. 413 - 421 (1999)

Update date:2022-08-05

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Authors:

Wuensch, Bernhard

Bauschke, Gerd

Diekmann, Heike

Hoefner, Georg

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Article abstract of DOI:10.1002/(SICI)1521-4184(199912)332:12<413::AID-ARDP413>3.0.CO;2-0

The key steps in the stereoselective synthesis of the tricyclic aminomethyl derivatives 19 and 20 and the aminoethyl substituted 1,3-dioxanes 24 and 25 are nucleophilic addition of aryllithium intermediates to the nitroalkene 13, intramolecular transaceta

Full text of DOI:10.1002/(SICI)1521-4184(199912)332:12<413::AID-ARDP413>3.0.CO;2-0

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