Bioorganic and Medicinal Chemistry Letters p. 3653 - 3660 (2017)
Update date:2022-08-02
Topics:
Shen, Fa-Qian
Wang, Zhong-Chang
Wu, Song-Yu
Ren, Shen-Zhen
Man, Ruo-Jun
Wang, Bao-Zhong
Zhu, Hai-Liang
In our previous study, we designed a series of pyrazole derivatives as novel COX-2 inhibitors. In order to obtain novel dual inhibitors of COX-2 and 5-LOX, herein we designed and synthesized 20 compounds by hybridizing pyrazole with substituted coumarin w
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