Bioorganic and Medicinal Chemistry Letters p. 2145 - 2148 (1998)
Update date:2022-08-05
Topics:
Fujishima, Toshie
Liu, Zhaopeng
Miura, Daishiro
Chokki, Manabu
Ishizuka, Seiichi
Konno, Katsuhiro
Takayama, Hiroaki
Synthesis and biological evaluation of all eight possible A-ring diastereomers of 2-methyl-20-epi-1,25-dihydroxyvitamin D3 are described. Among the analogues synthesized, 2α-methyl-20-epi-1α,25-dihydroxyvitamin D3 exhibited exceptionally high potency. The double modification of 2- methyl substitution and 20-epimerization yielded analogues with unique activity profiles.
View MoreJinan Hongfangde Pharmatech Co.LTD
Contact:0531-88870908
Address:F Bldg,750#,Shunhua Rd,New&High-tech Zone,Jinan,Shandong,China 250101
Contact:86-310-8067016
Address:East Fuhua Road,Tiexi Chemical Industrial Estate,Hebei,China
Contact:+86-710-3516804
Address:Number 83,Panggong road,Xiangcheng District,Xiangyang ,Hubei
Shanghai Gsyn Chemical Co.,Ltd.
Contact:86-021-67158290
Address:86-021-67158291
Contact:86-898-65311214
Address:Room 102, BLDG. 68 Jiangnan City, No. 66 Heping Road,Haikou, Hainan, China
Doi:10.1016/S0040-4020(99)01012-1
(2000)Doi:10.1039/c5nj01760b
(2015)Doi:10.1002/jlcr.2590050305
(1969)Doi:10.1021/jo991030r
(2000)Doi:10.1002/(SICI)1526-4998(200001)56:1<65::AID-PS90>3.0.CO;2-S
(2000)Doi:10.1016/S0040-4039(01)88477-X
(1969)