Synthesis and biological activity of 2-methyl-20-epi analogues of 1α,25-dihydroxyvitamin D3

DOI: 10.1016/S0960-894X(98)00363-1

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2145 - 2148 (1998)

Update date:2022-08-05

Topics:

Authors:

Fujishima, Toshie

Liu, Zhaopeng

Miura, Daishiro

Chokki, Manabu

Ishizuka, Seiichi

Konno, Katsuhiro

Takayama, Hiroaki

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00363-1

Synthesis and biological evaluation of all eight possible A-ring diastereomers of 2-methyl-20-epi-1,25-dihydroxyvitamin D₃ are described. Among the analogues synthesized, 2α-methyl-20-epi-1α,25-dihydroxyvitamin D₃ exhibited exceptionally high potency. The double modification of 2- methyl substitution and 20-epimerization yielded analogues with unique activity profiles.

Full text of DOI:10.1016/S0960-894X(98)00363-1

Products guided by the article

Product name:[(1R,3aR,4S,7aR)-1-((S)-3-Benzenesulfonyl-5-methoxymethoxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-4-yloxy]-tert-butyl-dimethyl-silane

Cas No:261905-61-7

R&D Labs maybe for 261905-61-7

JIAXING SUNS INTERNATIONAL TRADE CO LTD

Contact:18367306858

Address:No.123,Huixin Avenue,Huimin Dist
Qingdao S. H. Huanyu Imp. & Exp. Co., Ltd.

Contact:86-532-88250866

Address:Room 615, World Trade Centre Building B, Hongkong Middle Roda 6#, Qingdao, Shandong, China
ZHEJIANG JIANYE CHEMICAL CO.,LTD.

Contact:86-571-64149273,64149234

Address:No. 48, Fuxi Road, Meicheng Town
Taizhou volsen chemical Co., Ltd

website:http://www.volsenchem.com

Contact:+86-576-88869393

Address:Jiaojiang District, Taizhou, Zhejiang, China.
Zhejiang Golden-Shell Pharmaceutical Co.,Ltd.

Contact:+86-576-87501888 / 87501988

Address:No.89 Zhongxing Road. Li'ao, Yuhuan, Zhejiang, China

Relevant to this article

Tele nucleophilic aromatic substitutions in 1-nitro-3- and 1,3-dinitro- 5-trichloromethylbenzene, and 3-trichloromethylbenzonitrile. A new synthesis of the 1,4-benzothiazine-3(4H)-one ring system from 3 nitrobenzoic acid

Doi:10.1016/S0040-4020(99)01012-1
(2000)
Copper-catalyzed synthesis of aryldiazo sulfones from arylhydrazines and sulfonyl chlorides under mild conditions

Doi:10.1039/c5nj01760b
(2015)
Doi:10.1002/jlcr.2590050305
(1969)
Spiropentane Mimics of Nucleosides: Analogues of 2′-Deoxyadenosine and 2′-Deoxyguanosine. Synthesis of All Stereoisomers, Isomeric Assignment, and Biological Activity

Doi:10.1021/jo991030r
(2000)
Synthesis and insecticidal/acaricidal activity of novel 3-(2,4,6- trisubstituted phenyl)uracil derivatives

Doi:10.1002/(SICI)1526-4998(200001)56:1<65::AID-PS90>3.0.CO;2-S
(2000)
Doi:10.1016/S0040-4039(01)88477-X
(1969)

Article Doi