Bioorganic and Medicinal Chemistry Letters p. 2145 - 2148 (1998)
Update date:2022-08-05
Topics:
Fujishima, Toshie
Liu, Zhaopeng
Miura, Daishiro
Chokki, Manabu
Ishizuka, Seiichi
Konno, Katsuhiro
Takayama, Hiroaki
Synthesis and biological evaluation of all eight possible A-ring diastereomers of 2-methyl-20-epi-1,25-dihydroxyvitamin D3 are described. Among the analogues synthesized, 2α-methyl-20-epi-1α,25-dihydroxyvitamin D3 exhibited exceptionally high potency. The double modification of 2- methyl substitution and 20-epimerization yielded analogues with unique activity profiles.
View MoreBuffett (China) Holding Co.,Ltd
Contact:4006570891
Address:
HANGZHOU TOYOND BIOTECH CO., LTD
Contact:+86-571-86965177
Address:No. 189, Fengqi East Road, Hangzhou, China
Suzhou Kangrun Pharmaceutical, Inc
Contact:86-512-63912376,63913329
Address:Building 2, No. 2358 ,Chang'an Rd, Wujiang Economic Development Zone Pioneering park, china
ZHEJIANG JIANYE CHEMICAL CO.,LTD.
Contact:86-571-64149273,64149234
Address:No. 48, Fuxi Road, Meicheng Town
TIANJIN DONGRUXIANG MINERALS MARKETING CO.,LTD(expird)
Contact:22-58516360
Address:tianjin
Doi:10.1016/S0040-4020(99)01012-1
(2000)Doi:10.1039/c5nj01760b
(2015)Doi:10.1002/jlcr.2590050305
(1969)Doi:10.1021/jo991030r
(2000)Doi:10.1002/(SICI)1526-4998(200001)56:1<65::AID-PS90>3.0.CO;2-S
(2000)Doi:10.1016/S0040-4039(01)88477-X
(1969)