Bioorganic and Medicinal Chemistry p. 6323 - 6330 (2007)
Update date:2022-07-29
Topics:
Du, Wenting
Hong, Lan
Yao, Tongwei
Yang, Xiaochun
He, Qiaojun
Yang, Bo
Hu, Yongzhou
The synthesis of docetaxel esters of malic acid is described. These compounds were found to have greatly improved water solubility and are stable in solution at neutral pH. The C2′ modified compounds 2a-c and 3a-c behave as prodrugs, that is, docetaxel is
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