Tetrahedron Asymmetry p. 4841 - 4849 (1999)
Update date:2022-07-30
Topics:
Annunziata, Rita
Benaglia, Maurizio
Cinquini, Mauro
Cozzi, Franco
The synthesis of two 2-azetidinones possessing powerful cholesterol- absorption inhibition properties has been accomplished by a short and highly stereoselective reaction sequence. The key step is the condensation of the titanium enolate of the easily prepared 2-pyridylthioester (R)-11 with imine 6 which affords the desired β-lactam intermediate in the correct relative and absolute configuration. Conversion to the pharmacologically active compounds is readily accomplished by simple functional group manipulation. (C) 2000 Elsevier Science Ltd.
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