An expeditious synthesis of vibsanol, a benzofuran-type lignan from Viburnum awabuki

Article abstract of DOI:10.3987/com-99-s63

Vibsanol (1), a benzofuran-type lignan isolated from the wood of Viburnum awabuki (Caprifoliaceae), was synthesized from the readily available vanillin; the key step is a tandem cyclization of o-tert- butyldimethylsiloxydiarylalkyne (2) with tetrabutylammonium fluoride and excess paraformaldehyde.