1456
In summary, compound 2 has been successfully used as a novel camphor-derived auxiliary for the
[3+2] nitrile oxide cycloadditions to achieve high stereoselection. The efficient synthesis of 2 and the
mild conditions for the removal of the auxiliary make this methodology attractive. Further studies using
this chiral auxiliary to investigate its general utility for asymmetric synthesis are underway.
Acknowledgements
We thank the National Science Council of the Republic of China for financial support. The nitrile
oxides 4i–n provided by Professor C.-F. Yao (National Taiwan Normal University) is gratefully ac-
knowledged. The authors thank Professor C.-H. Ueng (National Taiwan Normal University) and Taipei
Instrumentation Center, College of Science (National Taiwan University) for X-ray crystal determination.
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