Bioorganic and medicinal chemistry letters p. 1625 - 1628 (2000)
Update date:2022-08-02
Topics:
Nantermet
Barrow
Selnick
Homnick
Freidinger
Chang
O'Malley
Reiss
Broten
Ransom
Pettibone
Olah
Forray
A series of alpha1a receptor antagonists derived from a 4-aryl-3,4-dihydropyridine-2-one heterocycle is disclosed. Potency in the low nanomolar to picomolar range along with high selectivity was obtained. In vivo efficacy in a prostate contraction model in rats was observed with a few derivatives.
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Doi:10.1016/S0957-4166(00)00443-2
(2000)Doi:10.1007/BF00590809
(1963)Doi:10.1021/ja992648l
(2000)Doi:10.1016/S0020-1693(99)00497-1
(2000)Doi:10.1002/jhet.5570370101
(2000)Doi:10.1021/jo990776m
(1999)