Synthesis of sulfoquinovosylacylglycerols, inhibitors of eukaryotic DNA polymerase α and β

Article abstract of DOI:10.1016/S0968-0896(00)00252-2

Sulfoquinovosyldiacylglycerols (SQDGs) and sulfoquinovosylmonoacylglycerols (SQMGs), bearing diverse fatty acids, were synthesized from d-glucose, and were examined for enzymatic inhibitions of DNA polymerase α and β. These results indicated that the carbon numbers of the fatty acids were highly related to the activities, at least in vitro, of eukaryotic DNA polymerase inhibition.