Nucleosides and nucleotides. 192. Toward the total synthesis of cyclic ADP-carbocyclic-ribose. Formation of the intramolecular pyrophosphate linkage by a conformation-restriction strategy in a syn-form using a halogen substitution at the 8-position of the

Article abstract of DOI:10.1080/15257770008033002

The synthesis of cyclic ADP-carbocyclic-ribose (2), as a stable mimic for cyclic ADP-ribose, was investigated. Construction of the 18-membered backbone structure was successfully achieved by condensation of the two phosphate groups of 19, possibly due to

Full text of DOI:10.1080/15257770008033002

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Nucleosides, Nucleotides and Nucleic
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Nucleosides and Nucleotides. 192.
Toward the Total Synthesis of Cyclic
ADP-Carbocyclic-Ribose. Formation
of the Intramolecular Pyrophosphate
Linkage by a Conformation-Restriction
Strategy in a Syn-form Using a Halogen
Substitution at the 8-Position of the
Adenine Ring
Yuji Sumita a , Michiyo Shirato a , Yoshihito Ueno a , Akira Matsuda a
& Satoshi Shuto a
a Graduate School of Pharmaceutical Sciences , Hokkaido
University , Kita-12, Nishi-6 Kita-ku, Sapporo, 060-0812, Japan
Published online: 24 Sep 2006.
To cite this article: Yuji Sumita , Michiyo Shirato , Yoshihito Ueno , Akira Matsuda & Satoshi Shuto
(2000) Nucleosides and Nucleotides. 192. Toward the Total Synthesis of Cyclic ADP-Carbocyclic-Ribose.
Formation of the Intramolecular Pyrophosphate Linkage by a Conformation-Restriction Strategy in a
Syn-form Using a Halogen Substitution at the 8-Position of the Adenine Ring, Nucleosides, Nucleotides
and Nucleic Acids, 19:1-2, 175-187, DOI: 10.1080/15257770008033002
To link to this article: http://dx.doi.org/10.1080/15257770008033002
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