STEROIDAL ALKALOIDS FROM THE BULBS OF FRITILLARIA PERSICA

Article abstract of DOI:10.1016/0031-9422(92)80470-Y

The methanolic extract of the fresh bulbs of Fritillaria persica has yielded five new steroidal alkaloids.Their structures have been shown by spectral analysis and chemical evidence to be (25R)-22,26-epimino-3β-hydroxy-5α-cholest-22(N)-en-6-one 3-O-β-D-glucopyranoside; (25R)-23,26-epimino-3β-hydroxy-5α-cholest-23(N)-ene-6,22-dione and its 3-O-glucoside, and their C-20 epimers.The inhibitory activity of the alkaloids on cyclic AMP phosphodiesterase was examined. Key Word Index: Fritillaria persica; Liliaceae; bulbs; steroidal alkaloids; cyclic AMP phosphodiesterase; inhibitory activity.