Synthesis of E- and Z-o-methoxy-substituted 2,3-diphenyl propenoic acids and its methyl esters

Article abstract of DOI:10.1080/00397910008087187

A series of stereoisomeric o-methoxy-substituted 2,3-diphenyl propenoic acids and their methyl esters have been synthesized. The E isomers were prepared by a modified Perkin condensation (substituted benzaldehyde, phenylacetic acid, Et₃N/acetic anhydride). The difficult to access Z isomers were obtained conveniently in good yields when the appropriate coumarin derivatives were allowed to react with KOH and CH₃I in DMSO.

Full text of DOI:10.1080/00397910008087187

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Synthetic Communications: An
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Synthesis of E- and Z-o-
Methoxy-Substituted 2,3-
Diphenyl Propenoic Acids and
Its Methyl Esters
Károly Felföldi a , Mária Sutyinszky a , Nóra Nagy a &
István Pálinkó a
a Department of Organic Chemistry , József Attila
University , Dóm tér 8, Szeged, H-6720, Hungary
Published online: 04 Dec 2007.
To cite this article: Károly Felföldi , Mária Sutyinszky , Nóra Nagy & István Pálinkó
(2000) Synthesis of E- and Z-o-Methoxy-Substituted 2,3-Diphenyl Propenoic Acids
and Its Methyl Esters, Synthetic Communications: An International Journal for
Rapid Communication of Synthetic Organic Chemistry, 30:9, 1543-1553, DOI:
10.1080/00397910008087187
To link to this article: http://dx.doi.org/10.1080/00397910008087187
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