A convenient synthesis of the orthogonally-protected benzodiazepine-2,5- dione scaffold

Article abstract of DOI:10.1080/00397910008087429

We have identified the benzodiazepine-2,5-dione 4 as a convenient, orthogonally-protected template, suitable for parallel solid-phase chemistry. Scaffold 4 offers superior stability, compared to other, analogous benzodiazepine-2,5-diones, such as A. We de

Full text of DOI:10.1080/00397910008087429

This article was downloaded by: [Moskow State Univ Bibliote]
On: 12 February 2014, At: 15:20
Publisher: Taylor & Francis
Informa Ltd Registered in England and Wales Registered Number: 1072954
Registered office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH,
UK
Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
Publication details, including instructions for
authors and subscription information:
http://www.tandfonline.com/loi/lsyc20
A Convenient Synthesis of
the Orthogonally-Protected
Benzodiazepine-2,5-Dione
Scaffold
Wieslaw M. Kazmierski a & John D. Mcdermed a
a Division of Medicinal Chemistry , Glaxo Wellcome
Inc. , Research Triangle Park, NC, 27709, USA
Published online: 04 Dec 2007.
To cite this article: Wieslaw M. Kazmierski & John D. Mcdermed (2000) A Convenient
Synthesis of the Orthogonally-Protected Benzodiazepine-2,5-Dione Scaffold, Synthetic
Communications: An International Journal for Rapid Communication of Synthetic
Organic Chemistry, 30:14, 2629-2634, DOI: 10.1080/00397910008087429
To link to this article: http://dx.doi.org/10.1080/00397910008087429
PLEASE SCROLL DOWN FOR ARTICLE
Taylor & Francis makes every effort to ensure the accuracy of all the
information (the “Content”) contained in the publications on our platform.
However, Taylor & Francis, our agents, and our licensors make no
representations or warranties whatsoever as to the accuracy, completeness,
or suitability for any purpose of the Content. Any opinions and views
expressed in this publication are the opinions and views of the authors, and
are not the views of or endorsed by Taylor & Francis. The accuracy of the
Content should not be relied upon and should be independently verified with
primary sources of information. Taylor and Francis shall not be liable for any

losses, actions, claims, proceedings, demands, costs, expenses, damages,
and other liabilities whatsoever or howsoever caused arising directly or
indirectly in connection with, in relation to or arising out of the use of the
Content.
This article may be used for research, teaching, and private study purposes.
Any substantial or systematic reproduction, redistribution, reselling, loan,
sub-licensing, systematic supply, or distribution in any form to anyone is
expressly forbidden. Terms & Conditions of access and use can be found at
http://www.tandfonline.com/page/terms-and-conditions