Journal of Organic Chemistry p. 3887 - 3891 (1981)
Update date:2022-08-05
Topics:
Wilson, Stephen R.
Sawicki, Robert A.
Huffman, J. C.
Application of transannular cyclizations to the synthesis of bridged pyrrolizidine alkaloids such as loline (1) is described.The general method involves bromination of 3-aza-9-oxabicyclo<4.2.1>non-7-ene (5), leading directly to the skeleton (12a) of the lolium alkaloids.Unsuccessful attempts to replace the bromine are described.The X-ray structure of the synthetic compound 12a as well as loline itself (1) and the biogenesis of lolium alkaloids are also discussed.
View Morewebsite:http://www.sjc.com.tw
Contact:(886) 2-2396-6223
Address:14Fl., No. 99. Sec. 2, Jen Ai Road
Xi'an Kaixiang Photoelectric Technology Co., Ltd
website:http://www.kxmaterials.com/
Contact:86-29-15991651477
Address:Building 6, Biopharmaceutical Industry R&D Cluster Base, No. 16, Caotang 4th Road, Caotang Science and Technology Industrial Base, High-tech Zone, Xi'an City, Shaanxi Province, China
Shanghai PotentPharm Science and Technology Co.,Ltd
Contact:86-021-51969655
Address:Unit B, Building 18, No.300, Chuantu Rd,Pudong District, Shanghai 201202, China
website:http://www.tbbmed.com
Contact:86--21-50498136
Address:Room 6002, Building 7-1, No.160 Basheng Road,Pudong Area,Shanghai China
Hebei Think-Do Environment Co., Ltd
website:http://www.thinkdo-environment.com
Contact:0311-86510809-
Address:No 6, Shilian Middle Street, Circular Chemical Industry Park
Doi:10.1371/journal.pone.0216008
(2019)Doi:10.1016/S0040-4020(00)00457-9
(2000)Doi:10.1002/hlca.19710540711
(1971)Doi:10.1016/S0008-6215(00)80595-9
(1970)Doi:10.1016/S0040-4039(00)00916-3
(2000)Doi:10.1021/ja01177a002
(1949)
