Discovery of 6,11-ethano-12,12-diaryl-6,11-dihydrobenzo[b]quinolizinium cations, a novel class of N-methyl-D-aspartate antagonists

DOI: 10.1021/jm00001a006

Source and publish data:

Journal of Medicinal Chemistry p. 21 - 27 (1995)

Update date:2022-07-29

Topics:

Authors:

Subramanyam

Mallamo Mallamo

Dority Jr.

Earley Earley

Kumar Kumar

Aimone Aimone

Ault Ault

Miller Miller

Luttinger

DeHaven-Hudkins

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Article abstract of DOI:10.1021/jm00001a006

6,11-Ethano-12,12-diaryl-6,11-dihydrobenzo[b]quinolizinium cations 8, a novel class of N-methyl-D-aspartate (NMDA) antagonists acting at the phencyclidine site, have been identified. Structure-activity relationship studies around the lead compound 8a led

Full text of DOI:10.1021/jm00001a006

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