Journal of Organic Chemistry p. 2699 - 2712 (2019)
Update date:2022-08-03
Topics:
Sihag, Pinki
Jeganmohan, Masilamani
An Ir(III)-catalyzed oxidative cyclization of benzoic acids with propargyl alcohols to give substituted isocoumarins in a highly regioselective manner is described. This protocol has a broad substrate scope with high functional group tolerance. The observed isocoumarins were converted into biologically active tetracyclic indeno[2,1-c]isocoumarins by Lewis acid-mediated cyclization. A possible reaction mechanism is proposed and strongly supported by the detailed mechanistic investigation and DFT.
View MoreChongqing KonAo Health Co.,Ltd
Contact:13687578375
Address:wuhan hubei china
Qingdao S. H. Huanyu Imp. & Exp. Co., Ltd.
Contact:86-532-88250866
Address:Room 615, World Trade Centre Building B, Hongkong Middle Roda 6#, Qingdao, Shandong, China
Jiacheng-Chem Enterprises Limited(expird)
Contact:86-571-86711508
Address:19 Floor, CIBC Holley International Building, No. 198,Wuxing Road, Hangzhou, China,310020
Buffett (China) Holding Co.,Ltd
Contact:4006570891
Address:
Zhejiang Kaili Industrial Co., Ltd
Contact:+86-571-85241926
Address:lantian business center,No.18 Moganshan Road
Doi:10.1002/hlca.19320150159
()Doi:10.1016/S0040-4039(01)98377-7
(1970)Doi:10.1021/acs.organomet.1c00339
(2021)Doi:10.1016/j.ica.2009.09.045
(2009)Doi:10.1039/c4cy00488d
(2014)Doi:10.1021/jo01036a033
(1963)