Synthesis of 5-Methylisocytidine Derivatives

Article abstract of DOI:10.1007/BF00810888

N²-Substituted 5-methylisocytidine derivatives were synthesized from S²-methyl-2-thiothymine either by direct substitution of the methylthio group by an amino group and subsequent condensation with 1,2,3,5-tetra-O-acetyl-β-D-ribofuranose to give the acetylated nucleoside or by the opposite sequence first preparing an acetylated 5,S²-dimethyl-2-thiouridine followed by treatment with the appropriate amine.