A novel synthesis of thienopyridine, pyrroloquinolinothiophene, pyrazolopyridin-3-yl-phenylthiourea and thiazolylpyrazolopyridine derivatives

Article abstract of DOI:10.1080/10426509908044987

Dibenzalacetones 1a-c reacted with cyanothioacetamide (2) to give the new styrylpyridinethione derivatives 3a-c which were used as the starting materials for the synthesis of other several heterocyclic compounds. Reactions with chloroacetone (4), N-arylmaleimides 7a,b, and ethyl iodide gave 2-S-acetonyl pyridines 5a-c, pyrrolo[3,4-f]quinolines 9a-f, and 2-S-ethylpyridines 11a-c, respectively. Several cycloaddition reactions were carried out on 3a-c, 5a-c, and 6a-c with dienophiles 7a,b, to afford the corresponding cycloadducts 9a-f, 10a-f, and 8a-f, respectively. Structures were established based on elemental analyses and spectral data. The antimicrobial activity of the newly synthesized compounds was tested.

Full text of DOI:10.1080/10426509908044987

This article was downloaded by: [Colorado College]
On: 13 October 2014, At: 18:26
Publisher: Taylor & Francis
Informa Ltd Registered in England and Wales Registered Number: 1072954
Registered office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH,
UK
Phosphorus, Sulfur, and Silicon
and the Related Elements
Publication details, including instructions for
authors and subscription information:
http://www.tandfonline.com/loi/gpss20
A NOVEL SYNTHESIS
OF THIENOPYRIDINE,
PYRROLOQUINOLINOTHIOPHENE,
PYRAZOLOPYRIDIN-3-YL-
PHENYLTHIOUREA AND
THIAZOLYLPYRAZOLOPYRIDINE
DERIVATIVES
Fawzy A. Attaby a & Azza M. Abd El-Fattah a
a Chemistry Department, Faculty of Science , Cairo
University , Giza, A. R. Egypt
Published online: 04 Oct 2006.
To cite this article: Fawzy A. Attaby & Azza M. Abd El-Fattah (1999) A
NOVEL SYNTHESIS OF THIENOPYRIDINE, PYRROLOQUINOLINOTHIOPHENE,
PYRAZOLOPYRIDIN-3-YL-PHENYLTHIOUREA AND THIAZOLYLPYRAZOLOPYRIDINE
DERIVATIVES, Phosphorus, Sulfur, and Silicon and the Related Elements, 155:1,
253-270, DOI: 10.1080/10426509908044987
To link to this article: http://dx.doi.org/10.1080/10426509908044987
PLEASE SCROLL DOWN FOR ARTICLE
Taylor & Francis makes every effort to ensure the accuracy of all the
information (the “Content”) contained in the publications on our platform.
However, Taylor & Francis, our agents, and our licensors make no
representations or warranties whatsoever as to the accuracy, completeness,
or suitability for any purpose of the Content. Any opinions and views
expressed in this publication are the opinions and views of the authors, and

are not the views of or endorsed by Taylor & Francis. The accuracy of the
Content should not be relied upon and should be independently verified with
primary sources of information. Taylor and Francis shall not be liable for any
losses, actions, claims, proceedings, demands, costs, expenses, damages,
and other liabilities whatsoever or howsoever caused arising directly or
indirectly in connection with, in relation to or arising out of the use of the
Content.
This article may be used for research, teaching, and private study purposes.
Any substantial or systematic reproduction, redistribution, reselling, loan,
sub-licensing, systematic supply, or distribution in any form to anyone is
expressly forbidden. Terms & Conditions of access and use can be found at
http://www.tandfonline.com/page/terms-and-conditions