Stereoselective epoxidation of bis-sulfinyl alkenes and application to the asymmetric synthesis of α-substituted carboxylic acids

Article abstract of DOI:10.1080/10426509708545544

Ketene thioacetals 3 can be easily prepared in optically pure form and react diastereoselectively with metal peroxides. The resulting bis-sulfinyl oxiranes can be converted in a single step to α-substituted acids.

Full text of DOI:10.1080/10426509708545544

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Phosphorus, Sulfur, and Silicon
and the Related Elements
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Stereoselective Epoxidation
of bis-Sulfinyl Alkenes and
Application to the Asymmetric
Synthesis of α-Substituted
Carboxylic Acids
Varinder K. Aggarwal , Julia M. Worrall & Rikki Alexander
a Department of Chemistry , University of Sheffield ,
Sheffield, S3 7HF, UK
b Department of Chemistry , University of Sheffield ,
Sheffield, S3 7HF, UK
c Celltech Therapeutics Limited , 216 Bath Road, Slough
SL1 4EN, UK
Published online: 17 Mar 2008.
To cite this article: Varinder K. Aggarwal , Julia M. Worrall & Rikki Alexander (1997)
Stereoselective Epoxidation of bis-Sulfinyl Alkenes and Application to the Asymmetric
Synthesis of α-Substituted Carboxylic Acids, Phosphorus, Sulfur, and Silicon and the
Related Elements, 120:1, 351-352, DOI: 10.1080/10426509708545544
To link to this article: http://dx.doi.org/10.1080/10426509708545544
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