New analogue of arenastatin A, a potent cytotoxic spongean depsipeptide, with anti-tumor activity

Article abstract of DOI:10.1016/j.bmcl.2004.02.080

Two analogues possessing steric hindered substituents on C-15 of arenastatin A (1), a potent cytotoxic spongean depsipeptide, were synthesized and shown to enhance stability in mouse serum. Notably, 15-tert-butylanalogue (6) with higher cytotoxicity exhib