3-Acyloxy-2-phenalkylpropyl amides and esters of homovanillic acid as novel vanilloid receptor agonists

DOI: 10.1016/S0960-894X(99)00513-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2909 - 2914 (1999)

Update date:2022-08-05

Topics: Pharmacological evaluation Esterification In vitro Testing In Vivo Testing Structure-Activity Relationship (SAR) Biological assay Agonist Synthetic derivatives

Authors:

Lee, Jeewoo

Park, Shin-Ung

Kim, Ji-Young

Kim, Jin-Kwan

Lee, Jiyoun

Oh, Uhtaek

Marquez, Victor E.

Beheshti, Maryam

Wang, Qiming J.

Modarres, Shayan

Blumberg, Peter M.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(99)00513-2

A series of 3-acyloxy-2-phenalkylpropyl amides and esters of homovanillic acid were designed and synthesized as vanilloid receptor agonists containing the three principal pharmacophores of resiniferatoxin. Amide analogues 23, 5 and 11 were found to be potent agonists in vanilloid receptor assay both for ligand binding and for activation.

Full text of DOI:10.1016/S0960-894X(99)00513-2

Products guided by the article

Product name:1-(tert-butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-propan-2-ol

Cas No:302783-31-9

R&D Labs maybe for 302783-31-9

QINGDAO DEVELOP chemistry Co.,Limited

Contact:+86-532-85807910

Address:98#Nanjing Road, Qingdao, China 266071
Hangzhou yi lu biont technology Co., LTD

Contact:+86-571-88152630

Address:Hangzhoushi HuafengRoad Yicheng3Building1001room.
ZHIJIANG ZENVA SINO COMMERCE AND TRADE CO., LTD.

website:http://www.zenvasino.com

Contact:+86-138-72658998

Address:Shibeishan Road,Zhijiang, Hubei, China
Shanghai Forever Synthesis Co.,Ltd.

Contact:021-61124658

Address:Zhoukang Road,Pudong New District,Shanghai,China
Lonwin Chemical Group Limited

website:http://www.lonwinchem.com

Contact:Tel: 86-21-59858395

Address:No#966,Huaxu Road,Shanghai 201702,P.R.China

Relevant to this article

A One-Pot Cascade Reaction by Combining NH-Sulfoximines with Thiophenols Under Mild Conditions

Doi:10.1002/ejoc.201701643
(2018)
Doi:10.1016/S0040-4039(00)99732-6
(1970)
Solution-phase preparation of a 560-compound library of individual pure mappicine analogues by fluorous mixture synthesis

Doi:10.1021/ja026947d
(2002)
Investigation of tightly coupled porphyrin arrays comprised of identical monomers for multibit information storage

Doi:10.1021/jo000489e
(2000)
Activation energies for the 1,2-carbon migration of ring-fused cyclopropylchlorocarbenes

Doi:10.1016/j.tetlet.2005.03.209
(2005)
Neighboring-group participation in carbohydrate chemistry. II. Neighboring-group participation of the N,N-diethylamido group in a nucleophilic displacement of a 5-tosylate.

Doi:10.1021/jo00820a030
(1971)

Article Doi