Journal of the Iranian Chemical Society p. 297 - 313 (2014)
Update date:2022-08-05
Topics:
Sirajuddin, Muhammad
Ali, Saqib
Shah, Farooq Ali
Ahmad, Muhammad
Tahir, Muhammad Nawaz
Eight different di- and triorganotin(IV) complexes of vanillin-Schiff base of the type R2SnClL and R3SnL [R = Me (1,6), n-Bu (2,7), Ph (3,8), tert-Bu (4), Cy (5) and L = 4-((3,5-dimethylphenylimino)methyl)-2- methoxyphenol] were synthesized. The products were characterized by elemental analysis, FT-IR, 1H, 13C and 119Sn NMR spectroscopy. The ligand 4-((3,5-dimethylphenylimino)methyl)-2-methoxyphenol is also characterized by single crystal X-ray analysis. In the 1H NMR spectra of 1 and 6, the 2 J(119/117Sn-1H) in the Sn-CH3 moiety has 57 and 54 Hz values, respectively, that confirm the formation of four-coordinated Sn species. Moreover, the 13C NMR value for ipso carbon of SnPh is 139 ppm which also confirms the formation of four-coordinated Sn species. The title ligand and its complexes were also screened for their biological activities such as interaction with DNA, enzymatic, antimicrobial, cytotoxic and antioxidant activities. The antimicrobial and cytotoxic activities of triorganotin(IV) derivatives are relatively higher than their corresponding diorganotin(IV) analogues due to their greater lipophilicity and permeability through cell membrane. Graphical abstract: [Figure not available: see fulltext.]
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