Bioorganic and Medicinal Chemistry Letters p. 2279 - 2282 (2001)
Update date:2022-08-05
Topics:
Su, Ting
Wu, Yanhong
Doughan, Brandon
Kane-Maguire, Kim
Marlowe, Charles K
Kanter, James P
Woolfrey, John
Huang, Brian
Wong, Paul
Sinha, Uma
Park, Gary
Malinowski, John
Hollenbach, Stan
Scarborough, Robert M
Zhu, Bing-Yan
A series of glycolic and mandelic acid derivatives was synthesized and investigated for their factor Xa inhibitory activity. These analogues are highly potent and selective inhibitors against fXa. In a rabbit deep vein thrombosis model, compound 26 showed
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