Synthesis and Biological Evaluation in Human Monocyte-Derived Macrophages of N-(N-Acetyl-L-cysteinyl)-S-acetylcysteamine Analogues with Potent Antioxidant and Anti-HIV Activities

Article abstract of DOI:10.1021/jm030374d

We synthesized a series of N-(N-acetyl-L-cysteinyl)-S-acetylcysteamine (10) analogues bearing various acyl groups on thiol cysteine or cysteamine residues, to investigate the structure-activity relationship for pro-GSH and anti-HIV properties in human mac