Localization of low molecular weight 99mTc-labeled dimercaptodicarboxylic acids in kidney tissue

Article abstract of DOI:10.1002/jps.2600680528

Kidney localization of low molecular weight (99m)Tc-dimercaptodicarboxylic acid complexes was examined in mice. The complexes (99m)Tc-dimercaptosuccinic acid, (99m)Tc-dimercaptoglutaric acid, and (99m)Tc-dimercaptoadipic acid were formed by reducing sodium (99m)Tc-pertechnetate with stannous chloride in the presence of 2-10 fold excess ligand at pH 2.5 or 7.5. Kidney specificity decreased as chain length between the mercapto groups increased. Optimum kidney retention occurred with complexes formed at pH 2.5. Complexes prepared at pH 7.5 were rapidly excreted through the urine ad feces. Kidney localization of complexes prepared at one pH was not altered if the pH was later changed.