On the coordinating behaviour of trimethoprim towards some metal ions

Article abstract of DOI:10.1080/00945719909349453

Complexes of 2,4-diamino-5-(3′,4′,5′-trimethoxybenzyl)pyrimidine (trimethoprim, TMP) with Ag(I), Zn(II), Cd(II), Hg(II) and Ni(II) have been prepared and characterized on the basis of elemental analyses, infrared and UV-Visible spectral and thermal data. Elemental analysis data show that the metal to ligand ratio is 1:1 in the Hg(II), Cd(II) and Ni(II) complexes and 1:2 in the Ag(I) and Zn(II) complexes. The infrared data show that trimethoprim acts as a monodentate ligand coordinating through the 4-NH₂ group of trimethoprim. Heats of fusion of the complexes have been calculated from the parameters of the DSC curves and the order of thermal stability of the complexes as deduced from the heat of fusion follows the trend: Ag(I) > Ni(II) > Hg(II) > Cd(II) > Zn(II).

Full text of DOI:10.1080/00945719909349453

Synthesis and Reactivity in Inorganic and Metal-Organic
Chemistry
ISSN: 0094-5714 (Print) 1532-2440 (Online) Journal homepage: http://www.tandfonline.com/loi/lsrt19
On the Coordinating Behaviour of Trimethoprim
Towards Some Metal Ions
B. S. Sekhon , H. S. Randhawa & Harvinder K. Sahai
To cite this article: B. S. Sekhon , H. S. Randhawa & Harvinder K. Sahai (1999) On the
Coordinating Behaviour of Trimethoprim Towards Some Metal Ions, Synthesis and Reactivity in
Inorganic and Metal-Organic Chemistry, 29:2, 309-321, DOI: 10.1080/00945719909349453
To link to this article: http://dx.doi.org/10.1080/00945719909349453
Published online: 14 Apr 2008.
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Date: 13 June 2016, At: 19:09