Bioorganic and Medicinal Chemistry Letters p. 1719 - 1723 (2014)
Update date:2022-08-04
Topics:
Mishra, Amita
Batchu, Harikrishna
Srivastava, Kumkum
Singh, Pratiksha
Shukla, Pravin K.
Batra, Sanjay
Synthesis and bioevaluation of new diaryl ether hybridized quinoline derivatives as antiplasmodial, antibacterial and antifungal agents is reported. It was encouraging to discover that several compounds displayed 2-3 folds better efficacy than chloroquine in chloroquine-resistant K1 strain of Plasmodium falciparum. Further, a few members of the library displayed good antibacterial efficacy against gram positive strains of bacteria but none of the compounds displayed any significant antifungal activity.
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