Journal of the Chemical Society. Chemical communications p. 1559 - 1560 (1994)
Update date:2022-08-04
Topics:
Bailey
Collier
Hollinshead
Moore
Morgan
Smith
Vernon
When the homologated nitrile 11 derived from L-tryptophan undergoes a modified Pictet-Spengler reaction with methyl propynoate, the resulting cis-tetrahydro-β-carboline 12a is ideally functionalised for cyclisation to the bridged ketonitrile 14; simple functional group modifications via the nitrile 15 (structure confirmed by X-ray crystallography) allow convergence with the tetracyclic α,β-unsaturated aldehyde 10, which is an advanced intermediate for the synthesis of a range of bridged indole alkaloids.
View MoreShandong Hongxiang Zinc Co., Ltd
Contact:086-0311-66187879
Address:DaWang developing zone
Goldwills Pharmaceuticals Co., Ltd.
Contact:0916-2237889 13991621155
Address:North Suburb of Hanzhong city, Shaanxi Province
Contact:+86-158-05817090
Address:ROOM 9F, FLAT 2, GUODU DEVELOPING BLDG, No.182, ZHAOHUI ROAD
KA-SHING Business Trade Macau Co., Ltd.
Contact:00853-28430045
Address:23rd Floor, Block 3 La Cite, Areia Preta, Macao
Shenzhen ZheYi Chemicals Co.,LTD(Shanghai Branch)
Contact:+86-21-54159691
Address:Room1002,Building No.2, Lane 98 Bixiu Road,Minhang District, Shanghai,China 201100
Doi:10.1021/jo000479d
(2000)Doi:10.1016/j.bmc.2003.08.003
(2003)Doi:10.1021/jm000240p
(2000)Doi:10.1002/jhet.5570370517
(2000)Doi:10.1016/S0022-1139(02)00329-9
(2003)Doi:10.1016/j.tet.2012.11.090
(2013)
