Journal of the Chemical Society. Chemical communications p. 1559 - 1560 (1994)
Update date:2022-08-04
Topics:
Bailey
Collier
Hollinshead
Moore
Morgan
Smith
Vernon
When the homologated nitrile 11 derived from L-tryptophan undergoes a modified Pictet-Spengler reaction with methyl propynoate, the resulting cis-tetrahydro-β-carboline 12a is ideally functionalised for cyclisation to the bridged ketonitrile 14; simple functional group modifications via the nitrile 15 (structure confirmed by X-ray crystallography) allow convergence with the tetracyclic α,β-unsaturated aldehyde 10, which is an advanced intermediate for the synthesis of a range of bridged indole alkaloids.
View MoreXi'an Costrong Pharmaceutical Co., Ltd.
Contact:029- 68576496
Address:Room 2004,Shuibao Building,No.190,South Erhuan Rd, Yanta District,Xi'an,Shaan Xi,China
Basilea Pharmaceutica China Ltd.
Contact:+86-513-82198075
Address:No.638 Xiushan Road(East),Haimen, Jiangsu 226100, P.R.China
website:http://www.sagechem.com
Contact:+86-571-86818502
Address:Room C1301, New Youth Plaza, 8 Jia Shan Road, Hangzhou, China
Anhui Sholon New Material Technology Co., Ltd.
website:http://www.sholonchem.com
Contact:+86-550-5261666
Address:4/F Block B, Beijing Chemical Building.No.520 Tianrun Road ,Science & Education Town Wujin District, Changzhou City Jiangsu Province
Contact:+86-535-8888888
Address:No.161 Haishi Rd.
Doi:10.1021/jo000479d
(2000)Doi:10.1016/j.bmc.2003.08.003
(2003)Doi:10.1021/jm000240p
(2000)Doi:10.1002/jhet.5570370517
(2000)Doi:10.1016/S0022-1139(02)00329-9
(2003)Doi:10.1016/j.tet.2012.11.090
(2013)
